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STRUCTURAL BIOLOGY: Dynamic Visions of Enzymatic Reactions

Access to the article is free, however registration and sign-in are required. The conformations of all proteins constantly fluctuate, but are these motions simply inherent properties of molecules held together by relatively weak interactions, or have they evolved to enhance their functional efficiency? There is increasing evidence that both views may in fact have validity and that biology has channeled the inherent motions of proteins into directions that enhance their effectiveness. Boehr et al. report experimental evidence that offers support to that view. They also indicate that many fluctuations can be linked together into whole reaction cycles that carry out a complex chemical process with great efficacy.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Michele Vendruscolo of Department of Chemistry, University of Cambridge, Christopher M. Dobson of Department of Chemistry, University of Cambridge
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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