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BIOCHEMISTRY: De Novo Design of an Enzyme

Access to the article is free, however registration and sign-in are required. Enzymes catalyze biological reactions with amazing efficiency, and years of biochemical research have been directed at understanding how they work. In their Perspective, Sterner and Schmid describe recent work (Dwyer et al.) that brings us closer to the ultimate goal of designing enzymes with tailored activities by using computer design to build catalytic activity onto an inert protein scaffold.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Reinhard Sterner of Universit├Ąt Regensburg, Franz X. Schmid of Institut f├╝r Biophysik und Physikalische Biochemie
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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