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STRUCTURAL BIOLOGY: Controlling the Caspases

Access to the article is free, however registration and sign-in are required. Enzymes called caspases are the executioners of programmed cell death. The IAP (inhibitor of apoptosis) proteins suppress apoptosis by blocking caspase activity and this suppression can be relieved by Smac/DIABLO, a mitochondrial protein released into the cytosol in response to apoptotic stimuli. In their Perspective, Fesik and Shi discuss recent structural and biochemical studies that reveal the molecular basis for the inhibition of caspases by IAPs and the relief of IAP inhibition by Smac/DIABLO.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Stephen W. Fesik of Cancer Research, Abbott Laboratories, Yigong Shi of Global Pharmaceutical Research & Development, Princeton University
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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