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ENZYMOLOGY: Nickel to the Fore

Access to the article is free, however registration and sign-in are required: Nickel was long thought not to be important in biology, but now several enzymes are known to depend on nickel for activity. In his Perspective, Thauer highlights the report by Dobbek et al., whose high-resolution crystal structure of a nickel enzyme reveals a novel nickel cluster in the active site. The structure offers surprising insights into the active site and the likely mechanism through which the enzyme harvests electrons from carbon monoxide.

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Resource Type: Image, Journal article/Issue, Diagram
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Rudolf K. Thauer of Max Planck Institute for Terrestrial Microbiology
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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