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BIOCHEMISTRY: Five Golden Rings

Access to the article is free, however registration and sign-in are required. Despite its worldwide use as a food preservative for more than four decades, the antibiotic nisin has not induced widespread biological resistance (1-4), making its biosynthesis particularly intriguing. Li et al. report that the antibiotic nisin bears five rings of different sizes in its structure. The enzyme that catalyzes the five distinct cyclization reactions is flexible, yet stringent, enough to form each ring in the correct order and conformation.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: David W. Christianson of Roy and Diana Vagelos Laboratories, University of Pennsylvania
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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