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BIOCHEMISTRY: Intramembrane Proteases--Mixing Oil and Water

Access to the article is free, however registration and sign-in are required. The report that the newly characterized signal peptide peptidase is an aspartic protease that resembles presenilin (Weihofen et al.) has generated excitement among Alzheimer's disease (AD) researchers. As Wolfe and Selkoe explain in their Perspective, the new work supplements existing evidence that presenilin (which is mutated in a rare familial form of AD) is an aspartic protease responsible for the intramembranous cleavage of many substrates, including the amyloid precursor protein.

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Classifications


Resource Type: Journal article/Issue, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright


Authors and Editors: Michael S. Wolfe of Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Dennis J. Selkoe of Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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