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BIOCHEMISTRY: How to Make a Superior Cell

Access to the article is free, however registration and sign-in are required. Engineering cells and microbes to make a commercially valuable product has been successfully accomplished by introducing foreign genes into target cells (Zaslavskaia et al.). According to the Perspective by Stephanopoulos and Kelleher, successful gene modification may require intervention at multiple steps in a metabolic pathway to optimize the desired cellular properties. As the authors explain, this necessitates successive rounds of genetic modification and physiological evaluation, a strategy that forms the basis of metabolic engineering.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Gregory Stephanopoulos of Department of Chemical Engineering, Massachusetts Institute of Technology, Joanne Kelleher of Department of Physiology and Experimental Medicine, George Washington University School of Medicine and Health Sciences
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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