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BIOCHEMISTRY: One Ring to Rule a Superfamily of E3 Ubiquitin Ligases

Access to the article is free, however registration and sign-in are required. The ubiquitin pathway is a sophisticated enzyme pathway that targets unwanted intracellular proteins for degradation within the proteasome. Three papers in Science suggest that there exists a superfamily of E3 ubiquitin ligases (the enzymes that tether ubiquitin to the protein marking it for degradation) present in multiprotein complexes. In their Perspective, Mike Tyers and Andrew Willems discuss these findings and what they tell us about protein degradation in the cell.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Mike Tyers of University of Toronto, Samuel Lunenfeld Research Institute, Andrew R. Willems of University of Toronto, Mount Sinai Hospital
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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