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APOPTOSIS: A Cinderella Caspase Takes Center Stage

Access to the article is free, however registration and sign-in are required. It has been thought that permeabilization of mitochondria and release of cytochrome c is an early event in apoptosis that is required for activation of caspases, the enzyme executioners of the apoptotic cascade. However, in a Perspective, Kumar and Vaux explain new findings (Lassus et al.) that implicate an often ignored caspase, caspase-2, in the early stages of apoptosis prior to mitochondrial permeabilization.

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Classifications


Resource Type: Journal article/Issue, Review, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright


Authors and Editors: Sharad Kumar of Hanson Institute, David L. Vaux of Walter and Eliza Hall Institute
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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