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Update: Mammalian Cytochrome c Oxidase, a Molecular Monster Subdued

Access to the article is free, however registration and sign-in are required. The high-resolution crystal structure of mammalian cytochrome c oxidase, a key enzyme in aerobic metabolism, was recently reported in Science by Tsukihara et al. (1), and discussed in an accompanying Perspective (2). The original paper (1), a landmark achievement in protein structure analysis, described the structure of the six metal centers (two hemes, two copper centers, Mg, and Zn), information critical to understanding the energy-transforming activity of the enzyme. In this issue, Tsukihara et al. (3) now present the complete structure of bovine cytochrome c oxidase at name 2.8 resolution.

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Resource Type: Journal article/Issue, Review, Report
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Shelagh Ferguson-Miller of Department of Biochemistry, Michigan State University
Publisher: AAAS
Format: application/pdf
Copyright and other restrictions: Yes
Cost: No


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