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Chemical Etiology of Nucleic Acid Structure

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

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Resource Type: Journal article/Issue, Illustration, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Albert Eschenmoser of The Scripps Research Institute
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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