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Subcellular mRNA Localization in Animal Cells and Why It Matters

Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.

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Resource Type: Journal article/Issue, Illustration, Photograph
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Christine E. Holt of Department of Physiology, University of Cambridge, Simon L. Bullock of Development, Medical Research Council (MRC) Laboratory of Molecular Biology
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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