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Discovering High-Affinity Ligands for Proteins: SAR by NMR

A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a protein are identified, optimized, and linked together to produce high-affinity ligands. The method reduces the amount of chemical synthesis and time required for the discovery of high-affinity ligands and appears particularly useful in target-directed drug research.

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Resource Type: Journal article/Issue, Illustration, Teaching strategies & guidelines, Report
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Stephen Fesik of Abbott Laboratories, Robert Meadows of Abbott Laboratories, Suzanne B. Shuker of Abbott Laboratories, Philip J Hajduk of Abbott Laboratories
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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