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Discovering High-Affinity Ligands for Proteins

This article reports on development of a method for producing high-affinity ligands in which small molecules that bind to proximal subsites of a protein are identified in an NMR-based screen and then linked together in their experimentally determined bound orientations. The method is called “SAR by NMR,” which stands for “structure-activity relationships by nuclear magnetic resonance.”

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Resource Type: Journal article/Issue, Illustration, Review
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Stephen Fesik of Abbott Laboratories, Robert P. Meadows of Abbott Laboratories, Philip J Hajduk of Abbott Laboratories
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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