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Aging Is RSKy Business

Following hot on the heels of recent studies showing that dietary restriction slows aging in primates and that inhibiting the enzyme mammalian target of rapamycin (mTOR) increases life span in mice, a report by Selman et al. uncovers an important role for another enzyme, a ribosomal S6 protein kinase (RSK) called S6K1, as a determinant of mammalian aging. S6K1 is a target of mTOR, so the new finding further defines a conserved longevity pathway that links nutrient availability to aging in organisms as diverse as yeast and mice. The study also has potentially important implications for future attempts to increase longevity and slow the progression of age-associated diseases in humans.

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Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Matt Kaeberlein of Department of Pathology, University of Washington, Pankaj Kapahi of Buck Institute for Age Research
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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