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Blocking Akt-ivity

Aberrations in cellular signaling pathways that involve the enzyme Akt (also called protein kinase B) are implicated in diverse diseases, including cancer, diabetes, and neurodegenerative disorders. Thus, proteins involved in Akt activation and signaling are potential targets for therapeutic intervention. This perspective discusses a report by Yang et al., who have identified a chemical modification of Akt that controls its activation, identifying another potential means to inhibit this kinase in human cancers.

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Classifications


Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: David Restuccia of Friedrich Miescher Institute for Biomedical Research
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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