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Lethal Traffic Jam

This perspective discusses new discoveries on the effects of the antibiotics chloramphenicol and tetracycline. The antibiotics chloramphenicol and tetracycline were discovered in the late 1940s shortly after the introduction of penicillin. Elucidation of the structure of the ribosome revealed how they bind to this target structure and inhibit protein synthesis. In a recent report, van Stelten et al. demonstrate another mode of action for these antibiotics, involving the destruction of a complex that allows proteins to be translocated across (or into) the bacterial membrane.

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Resource Type: Journal article/Issue, Illustration
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Eefjan Breukink of Department of Chemical Biology and Organic Chemistry, Utrecht University
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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