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Connecting Organelles

This perspective discusses a recent report demonstrating the existence of a complex of proteins connecting mitochondria to the endoplasmic reticulum. Mitochondria are organelles that form a dynamic network in most eukaryotic cell types. Although originally considered to be semi-autonomous powerhouses, they are intimately connected to the rest of the cell through metabolic and signaling pathways, and play a central role in programmed cell death (apoptosis). Sites of close proximity between mitochondria and the tubular network of the endoplasmic reticulum have long been known from electron micrographs, yet their molecular nature remained elusive. In a recent report, Kornmann et al. show that a complex of proteins that controls mitochondrial shape and protein biogenesis bridge these two organelles.

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Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Nils Wiedemann of Institut f├╝r Biochemie und Molekularbiologie, Universit├Ąt Freiburg, Chris Meisinger of Zentrum f├╝r Biochemie und Molekulare Zellforschung and Centre for Biological Signalling Studies, Universit├Ąt Freiburg, Nikolaus Pfanner of Institut f├╝r Biochemie und Molekularbiologie, Universit├Ąt Freiburg
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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