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Principles of Selective Ion Transport in Channels and Pumps

This article discusses the architecture and detailed chemistry of the ion conduction pathways involved in selective ion transport. The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and detailed chemistry of the ion conduction pathways.

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Classifications


Resource Type: Journal article/Issue, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Eric Gouaux of Vollum Institute and Howard Hughes Medical Institute, Oregon Health and Sciences University, Roderick MacKinnon of Howard Hughes Medical Institute, Rockefeller University
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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