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Cell Migration: Integrating Signals from Front to Back

This article provides a review of current knowledge in the study of cell migration. Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.

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Resource Type: Journal article/Issue, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Anne Ridley of Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, Martin Schwartz of Departments of Microbiology and Biomedical Engineering, University of Virginia School of Medicine, Keith Burridge of Cardiovascular Research Center and Mellon Prostate Cancer Research Institute, University of North Carolina, Richard Firtel of Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of California, Mark Ginsberg of Section of Cell and Developmental Biology, The Scripps Research Institute, Gary Borisy of Division of Biological Sciences and Center for Molecular Genetics, Northwestern University, J. Thomas Parsons of Department of Cell Biology, School of Medicine, Alan Rick Horowitz of Department of Cellular and Molecular Biology, University of Virginia School of Medicine
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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