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Assembly of Cell Regulatory Systems Through Protein Interaction Domains

The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation. However, this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior. The regulation of many different cellular processes requires the use of protein interaction domains to direct the association of polypeptides with one another and with phospholipids, small molecules, or nucleic acids. The modular nature of these domains, and the flexibility of their binding properties, have likely facilitated the evolution of cellular pathways. Conversely, aberrant interactions can induce abnormal cellular behavior and disease. The fundamental properties of protein interaction domains are discussed in this review and in detailed reviews on individual domains at Science's STKE at http://www.sciencemag.org/cgi/content/full/300/5618/445/DC1.

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Classifications


Resource Type: Journal article/Issue, Review, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Tony Pawson of Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Piers Nash of Department of Medical Genetics and Microbiology, University of Toronto
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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