SIGN IN   Advanced Search

Browse Enzymology
Assembly of Cell Regulatory Systems Through Protein Interaction Domains

The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation. However, this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior. The regulation of many different cellular processes requires the use of protein interaction domains to direct the association of polypeptides with one another and with phospholipids, small molecules, or nucleic acids. The modular nature of these domains, and the flexibility of their binding properties, have likely facilitated the evolution of cellular pathways. Conversely, aberrant interactions can induce abnormal cellular behavior and disease. The fundamental properties of protein interaction domains are discussed in this review and in detailed reviews on individual domains at Science's STKE at http://www.sciencemag.org/cgi/content/full/300/5618/445/DC1.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.

View Free


Resource Type: Journal article/Issue, Review, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Tony Pawson of Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Piers Nash of Department of Medical Genetics and Microbiology, University of Toronto
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No


» Sign In or register to post comments.

American Association for the Advancement of Science



Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.