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Lysophospholipids--Receptor Revelations

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid mediators. LP receptor biology has generated insights into fundamental cellular mechanisms and may provide therapeutic targets for drug development.

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Resource Type: Journal article/Issue
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Timothy Hla of Center for Vascular Biology, University of Connecticut Health Center, Meng-Jer Lee of Department of Physiology, University of Connecticut Health Center, Nicolas Ancellin of Center for Vascular Biology, University of Connecticut Health Center, Ji Paik of Department of Physiology, University of Connecticut Health Center, Michael Kluk of Center for Vascular Biology, University of Connecticut Health Center
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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