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Mechanism of Actin-Based Motility

Spatially controlled polymerization of actin is at the origin of cell motility and is responsible for the formation of cellular protrusions like lamellipodia. The pathogens Listeria monocytogenes and Shigella flexneri, which undergo actin-based propulsion, are acknowledged models of the leading edge of lamellipodia. Actin-based motility of the bacteria or of functionalized microspheres can be reconstituted in vitro from only five pure proteins. Movement results from the regulated site-directed treadmilling of actin filaments, consistent with observations of actin dynamics in living motile cells and with the biochemical properties of the components of the synthetic motility medium.

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Resource Type: Journal article/Issue
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Dominique Pantoloni of Dynamique du Cytosquelette, CNRS, Christophe Le Clainche of Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Marie-France Carlier of Dynamique du Cytosquelette, CNRS
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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